abstract：:We chose synaptic terminals of rat rod bipolar cells as a model system to study activity-related changes in the overall morphology and the fine structure of synaptic sites. Using confocal laser scanning microscopy in conjunction with three-dimensional reconstruction and electron microscopy, we examined the effect of l...

journal_title：Cell and tissue research

authors： Behrens UD,Kasten P,Wagner HJ

更新日期：1998-11-01 00:00:00

abstract：:In the present study, we have analyzed the direct effects of cytokines, which mediate the acute-phase response in liver, on connexin expression and gap-junctional intercellular communication in immortalized MHSV12 mouse hepatocytes. When these cells were stimulated for 24 h with interleukin 1 and interleukin 6, the am...

journal_title：Cell and tissue research

authors： Temme A,Traub O,Willecke K

更新日期：1998-11-01 00:00:00

abstract：:The processes involved in the regulation of bone cell metabolism are complex, including those implicated in bone cell coupling. This study was undertaken to develop a model that would permit real-time interaction between osteoclastic cells and osteoblasts in vitro. Osteogenic bone marrow stromal cells were isolated fr...

journal_title：Cell and tissue research

authors： Loomer PM,Ellen RP,Tenenbaum HC

更新日期：1998-10-01 00:00:00

abstract：:SCO-spondin is a newly identified protein, strongly expressed in the subcommissural organ (SCO), an ependymal differentiation of the brain. When secreted into the cerebrospinal fluid at the entrance to the Sylvian aqueduct, it condenses and forms Reissner's fiber. Several conserved domains have previously been charact...

journal_title：Cell and tissue research

authors： Monnerie H,Dastugue B,Meiniel A

更新日期：1998-09-01 00:00:00

abstract：:The distribution and development of growth-associated protein 43 (GAP-43)-like immunoreactivity (-LI) in the rat circumvallate papilla (CVP) were compared to those of protein gene product 9.5 (PGP 9.5)-LI. In the adult, thick GAP-43-like immunoreactive (-IR) structures gathered densely in the subgemmal region. Some of...

journal_title：Cell and tissue research

authors： Wakisaka S,Daikoku H,Miyawaki Y,Youn SH,Maeda T,Kurisu K

更新日期：1998-09-01 00:00:00

abstract：:Interstitial cells in the myenteric plexus and the deep muscular plexus of the small intestine of the c-kit mutant rats (Ws/Ws) and their normal siblings (+/+) were studied. c-Kit immunoreactivity was detected in two regions corresponding to the myenteric plexus and the deep muscular plexus in the jejunum of +/+ rats,...

journal_title：Cell and tissue research

authors： Horiguchi K,Komuro T

更新日期：1998-08-01 00:00:00

abstract：:Substance P (SP) is a neuropeptide that is released from axons of sensory neurons and causes signal transduction through the activation of the neurokinin-1 receptor (NK1-R). The present study demonstrates the distribution of SP-like-immunoreactive (SP-LI) axons and the localization of NK1-Rs in rat bone tissue using t...

journal_title：Cell and tissue research

authors： Goto T,Yamaza T,Kido MA,Tanaka T

更新日期：1998-07-01 00:00:00

abstract：:Loss of wild-type p53 activity is thought to be a major predictor of failure to respond to radiotherapy and chemotherapy in various human cancers. This assumption is largely based on some cell-death studies in p53-knockout mice and on correlations of p53 status assessed by immunochemistry or single-strand conformation...

journal_title：Cell and tissue research

authors： Weller M

更新日期：1998-06-01 00:00:00

abstract：:Pancreatic acinar cells of euthermic, hibernating and arousing individuals of the hazel dormouse Muscardinus avellanarius (Gliridae) have been observed at the electron-microscopic level and analysed by means of ultrastructural morphometry and immunocytochemistry in order to investigate possible fine structural changes...

journal_title：Cell and tissue research

authors： Malatesta M,Zancanaro C,Marcheggiani F,Cardinali A,Rocchi MB,Capizzi D,Vogel P,Fakan S,Gazzanelli G

更新日期：1998-06-01 00:00:00

abstract：:While brain-derived neurotrophic factor (BDNF) messenger RNA (mRNA) has been localized in the developing gustatory epithelium, little information is available about neurotrophin-3 (NT-3) mRNA expression pattern in the prenatal developing gustatory and lingual epithelium. In the present study, using in situ hybridizati...

journal_title：Cell and tissue research

authors： Nosrat CA,Olson L

更新日期：1998-06-01 00:00:00

abstract：:Interstitial cells of Cajal (ICCs) are believed to be a major element in generating the spontaneous rhythm of the gastrointestinal tract. A prominent problem in the study of these cells has been the difficulty in observing them in intact tissues. We used the lipophilic dye DiI to stain ICCs in the submucosal-circular ...

journal_title：Cell and tissue research

authors： Hanani M,Louzon V,Miller SM,Faussone-Pellegrini MS

更新日期：1998-05-01 00:00:00

abstract：:The cutaneous glands of the forehead and the metatarsus were studied by histological and histochemical methods and electron microscopy in adult male and female impalas in various seasons of the year. All glandular areas consist of apocrine and holocrine glands, which, however, occur in different proportions. Our findi...

journal_title：Cell and tissue research

authors： Welsch U,van Dyk G,Moss D,Feuerhake F

更新日期：1998-05-01 00:00:00

abstract：:Agitation of villi evokes reflexes that affect the motility of the guinea-pig small intestine. NK1 receptor endocytosis was used to investigate the possible involvement of tachykinins acting on neuronal NK1 receptors in these reflexes. Segments of guinea-pig ileum were incubated at 37 degrees C in Krebs physiological ...

journal_title：Cell and tissue research

authors： Southwell BR,Woodman HL,Royal SJ,Furness JB

更新日期：1998-04-01 00:00:00

abstract：:The formylpeptide receptor (FPR), previously found only on polymorphonuclear leukocytes and monocytes/macrophages, responds to both synthetic N-formyl oligopeptides and those produced by bacteria. The cDNA for human FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptid...

journal_title：Cell and tissue research

authors： Becker EL,Forouhar FA,Grunnet ML,Boulay F,Tardif M,Bormann BJ,Sodja D,Ye RD,Woska JR Jr,Murphy PM

更新日期：1998-04-01 00:00:00

abstract：:Neurofilaments, which are exclusively found in nerve cells, are one of the earliest recognizable features of the maturing nervous system. The differential distribution of neurofilament proteins in varying degrees of phosphorylation within a neuron provides the possibility of selectively demonstrating either somata and...

journal_title：Cell and tissue research

authors： Ulfig N,Nickel J,Bohl J

更新日期：1998-03-01 00:00:00

abstract：:The dissociation and maintenance in culture of cells derived from the mushroom bodies of adult crickets (Acheta domesticus) are described. This primary culture was developed in order to investigate maturation and differentiation of mushroom-body cells including Kenyon cells, the major intrinsic interneurons of mushroo...

journal_title：Cell and tissue research

authors： Cayre M,Buckingham SD,Strambi A,Strambi C,Sattelle DB

更新日期：1998-03-01 00:00:00

abstract：:In Syrian hamsters (Mesocricetus auratus), oxytocin (OXT) activity within the medial preoptic-anterior hypothalamus (MPOA-AH) and the ventromedial hypothalamus (VMH) plays an important role in the expression of sexual receptivity. Immunocytochemical analysis with OXT-specific antibodies was used to identify the distri...

journal_title：Cell and tissue research

authors： Whitman DC,Albers HE

更新日期：1998-02-01 00:00:00

abstract：:The distribution and ultrastructure of the mitochondria-rich (MR) cells in the gills of larval (ammocoetes) and adult lampreys (Petromyzon marinus and Geotria australis) have been studied. One type of MR cell, which is found only in ammocoetes, occurs in groups on and between gill lamellae. Freeze-fracture replicas sh...

journal_title：Cell and tissue research

authors： Bartels H,Potter IC,Pirlich K,Mallatt J

更新日期：1998-02-01 00:00:00

abstract：:Glutamate is the major excitatory neurotransmitter of the mammalian retina and glutamate uptake is essential for normal transmission at glutamatergic synapses. The reverse transcriptase-polymerase chain reaction (RT-PCR) has revealed the presence of three different high-affinity glutamate transporters in the rat retin...

journal_title：Cell and tissue research

authors： Rauen T,Taylor WR,Kuhlbrodt K,Wiessner M

更新日期：1998-01-01 00:00:00

abstract：:The gene encoding H1t, a testicular variant of histone H1, is expressed in mammals during spermatogenesis. Northern blot and in situ hybridization has detected H1t mRNA only at the stage of pachytene spermatocytes. We have extended this analysis to more sensitive approaches and demonstrate, by RNase protection and ele...

journal_title：Cell and tissue research

authors： Drabent B,Bode C,Miosge N,Herken R,Doenecke D

更新日期：1998-01-01 00:00:00

abstract：:Proteins participating in vesicular docking and fusion have been identified in the nervous system. Such proteins appear to be important for the molecular regulation of exocytosis also in non-neuronal cells. The enterochromaffin-like (ECL) cells of the gastric acid-secreting (oxyntic) mucosa secrete histamine and chrom...

journal_title：Cell and tissue research

authors： Zhao CM,Jacobsson G,Chen D,Hâkanson R,Meister B

更新日期：1997-12-01 00:00:00

abstract：:Identified dorsal unpaired median (DUM) neurones of the locust Locusta migratoria were stained intracellularly with large amounts of cobalt to reveal their extensive peripheral branching patterns. Two neurones of the suboesophageal ganglion were studied as well as several neurones of thoracic ganglia. The peripheral b...

journal_title：Cell and tissue research

authors： Braunig P

更新日期：1997-12-01 00:00:00

abstract：:Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially wit...

journal_title：Cell and tissue research

authors： Alvarez-Bolado G,Schwarz M,Gruss P

更新日期：1997-11-01 00:00:00

abstract：:Neurotrophins NGF, BDNF, NT-3, and NT-4/5 are members of the neurotrophin family of proteins, which support the survival and induce differentiation of vertebrate neurons. We have studied the effects of neurotrophins on growth cones of embryonic sensory neurons. BDNF and NT-4/5 cause growth cone collapse and transient ...

journal_title：Cell and tissue research

authors： Paves H,Saarma M

更新日期：1997-11-01 00:00:00

abstract：:Whether an axon will regenerate after it is cut depends on the balance between the intrinisic ability of the axon to regrow and the permissiveness of the environment surrounding it. The permissiveness of the environment is determined by the glial cells at the site of injury, and in the CNS both oligodendrocytes and as...

journal_title：Cell and tissue research

authors： Fawcett JW

更新日期：1997-11-01 00:00:00

abstract：:The present review describes several lines of recent evidence providing new insights into the basic principles and mechanisms of axon projection from the olfactory epithelium to the olfactory bulb. Olfactory sensory neurons are classified into approximately 1000 subtypes according to the expression of specific odorant...

journal_title：Cell and tissue research

authors： Yoshihara Y,Mori K

更新日期：1997-11-01 00:00:00

abstract：:The fate of the major connective tissue polysaccharide hyaluronan, as it appears after release from the matrix, was studied in the Atlantic cod by use of subcutaneous administration of hyaluronan conjugated with fluorescein isothiocyanate (FITC) and labelled with 125I. After administration, the ligand was transported ...

journal_title：Cell and tissue research

authors： Sorensen KK,Dahl LB,Smedsrod B

更新日期：1997-10-01 00:00:00

abstract：:Striated rootlets in ciliated cells are conical banded structures composed of longitudinally aligned filaments. The formation of striated rootlets during ciliognesis in the human oviduct epithelium was studied by electron microscopy. Primitive rootlets appeared at the proximal side of basal bodies before or at the sam...

journal_title：Cell and tissue research

authors： Hagiwara H,Aoki T,Ohwada N,Fujimoto T

更新日期：1997-10-01 00:00:00

abstract：:We investigated the binding characteristics of two monoclonal antibodies, 4F3 and 3F8, which in the retina specifically stain Müller cells, both with protein blots and immunohistochemically in sections of various regions of the central nervous system of neonatal and adult cats and rats. Clear differences emerged betwe...

journal_title：Cell and tissue research

authors： Distler C,Bronzel M,Paas I,Wahle P

更新日期：1997-09-01 00:00:00

abstract：:Neuromuscular terminals of a single motoneuron to four muscles (CPV7a, GM5a, CV2, and CV3) in the stomach of the blue crab Callinectes sapidus showed structural evidence for the exocytotic release of dense-core vesicles exclusively at synapses. The primary evidence was the appearance of dense cores in the synaptic cle...

journal_title：Cell and tissue research

authors： Patel V,Govind CK

更新日期：1997-09-01 00:00:00

abstract：:The distribution of neuropeptide Y (NPY)-like immunoreactivity in the brain of the bichir, Polypterus senegalus, was examined immunohistochemically. NPY-like immunoreactivity was distributed widely in the brain, with the highest density in the diencephalon. NPY-positive perikarya were found in various areas, including...

journal_title：Cell and tissue research

authors： Chiba A

更新日期：1997-08-01 00:00:00

abstract：:A culture technique for the in vitro growth and differentiation of antennal cells of Mamestra brassicae is described. The morphology of the growing cells is described. At least five morphological cell types can be distinguished in the cultures. Neuronal cells (type A) were characterized morphologically and immunocytoc...

journal_title：Cell and tissue research

authors： Lucas P,Nagnan-Le Meillour P

更新日期：1997-08-01 00:00:00

abstract：:The saccular membranes of trout (Oncorhynchus mykiss) and turbot (Scophthalmus maximus) were examined to characterize specialized epithelial cells that might be responsible for ion exchange. The approach for localizing cell types was new for this tissue, as observations were made with a stereomicroscope and a light mi...

journal_title：Cell and tissue research

authors： Mayer-Gostan N,Kossmann H,Watrin A,Payan P,Boeuf G

更新日期：1997-07-01 00:00:00

abstract：:The production of nerve growth factor (NGF) in peripheral organs may play a role in the pathophysiology of hypertension and in obstructive disorders of the bladder outlet. We have been examining the cellular processes of NGF delivery and secretion in smooth muscle. NGF secretion from vascular smooth muscle cells (VSMC...

journal_title：Cell and tissue research

authors： Sherer TB,Spitsbergen JM,Steers WD,Tuttle JB

更新日期：1997-07-01 00:00:00

abstract：:Previous investigations have demonstrated that peripheral insulin has a significant influence on brain function and that the interaction of insulin with neuropeptides in neuroendocrine regions may be pivotal for the regulation of body metabolism and energy balance. Since the various levels of interactions are only inc...

journal_title：Cell and tissue research

authors： Unger JW,Lange W

更新日期：1997-06-01 00:00:00

abstract：:The distribution of FMRFamide-like immunoreactive cell bodies and fibers in the nervous system of the earthworm Lumbricus terrestris has been studied by means of immunocytochemistry. The cerebral ganglion contains 150-170 immunoreactive nerve cells that are organized into six major groups in the rostral and five major...

journal_title：Cell and tissue research

authors： Reglödi D,Slezák S,Lubics A,Szelier M,Elekes K,Lengvári I

更新日期：1997-06-01 00:00:00

abstract：:Tenidap is a structurally novel antirheumatic agent with anti-inflammatory and analgesic properties. Previous studies have shown that tenidap is able to inhibit the production and action of cytokines such as interleukin-1, interleukin-6 (IL-6) and tumour necrosis factor alpha. However, the mechanisms by which tenidap ...

journal_title：Cell and tissue research

authors： Lieb K,Fiebich BL,Hüll M,Berger M,Bauer J

更新日期：1997-05-01 00:00:00

abstract：:Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue e...

journal_title：Cell and tissue research

authors： Belloni AS,Pacheco YG,Markowska A,Andreis PG,Meneghelli V,Malendowicz LK,Nussdorfer GG

更新日期：1997-05-01 00:00:00

abstract：:The extracellular matrix is involved in various morphogenetic processes which are accompanied by changes in its physicochemical properties and spatial organization. In the adult brain it contributes to cellular communication and the regulation of neuronal activity. The present study deals with the postnatal appearance...

journal_title：Cell and tissue research

authors： Köppe G,Brückner G,Brauer K,Härtig W,Bigl V

更新日期：1997-04-01 00:00:00

abstract：:A quantitative evaluation of putative amino acid neurotransmitters in sea pansy polyps by high-performance liquid chromatography indicates that the taurine content exceeds that of other amino acids by a 100-fold. The cellular source of this taurine was investigated by immunohistochemistry with two polyclonal antisera ...

journal_title：Cell and tissue research

authors： Anctil M,Minh CN

更新日期：1997-04-01 00:00:00